Prodigiosin Serratia marcesc 1PC X 200UG

Code: 529685-200UG D2-231

General description

A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistanc...


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€165.63 EACH
€203.72 inc. VAT

General description

A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Schinske, K.A., et al. 2011. Mol. Cancer Ther.10, 1807.Chang, C.C., et al. 2011. J. Biosci. Bioeng.5, 501Ho, T.F., et al. 2009. Toxicol. Appl. Pharmacol.235, 253Soto-Cerrato, V., et al. 2007.Mol. Cancer Ther.6, 362.

Packaging

Packaged under inert gas

200 µg in Glass bottle

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)

assay≥95% (HPLC)
colordark red
formsolid
InChI keyWKGQSEFBQTWRPT-FHUUTLRSSA-N
InChI1S/C20H25N3O/c1-4-5-6-8-15-11-16(22-14(15)2)12-19-20(24-3)13-18(23-19)17-9-7-10-21-17/h7,9-13,22-23H,4-6,8H2,1-3H3/b18-17+,19-12+
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inambient
SMILES stringCC1=C(CCCCC)C=C(/C=C2N=C(C3=CC=CN3)C=C2OC)N1
solubilitymethanol: soluble, DMF: soluble, ethanol: soluble, DMSO: soluble
storage conditionprotect from light, OK to freeze
storage temp.−20°C
Cas Number82-89-3
This product has met the following criteria to qualify for the following awards:



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